On the millisecond timescale, neurons communicate primarily by releasing neurotransmitters from presynaptic specializations along their axons in response to action potential firing, with the increased concentration of neurotransmitters acting to open ligand-gated ion channels largely concentrated in postsynaptic specializations on dendrites.
In the future, it will be important to assess if the diversity of axonal projections across individual layer 2/3 mouse barrel cortex neurons is accompanied by functional differences in their activity patterns. In addition, individual neurons innervated subsets of secondary somatosensory cortex primary somatosensory cortex for upper limb, trunk, and lower limb primary and secondary motor cortex visual and auditory cortical regions dorsolateral striatum and various fiber bundles. Each neuron had an extensive local axon within the barrel cortex.
#Axon face2face serial
Here, we develop and test methodology for imaging and annotating the brain-wide axonal arborizations of individual excitatory layer 2/3 neurons in mouse barrel cortex through single-cell electroporation and two-photon serial section tomography followed by registration to a digital brain atlas. On the millisecond time scale, information is signaled from one brain area to another by action potentials propagating across long-range axonal arborizations. Laboratory of Sensory Processing, Brain Mind Institute, Faculty of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, SwitzerlandĬommunication between cortical areas contributes importantly to sensory perception and cognition.Yanqi Liu †, Georgios Foustoukos †, Sylvain Crochet and Carl C.H.
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