Treating Cancer-Related Hypercalcemia with Gallium Nitrate. Medical applications and toxicities of gallium compounds. Collery P, Keppler B, Madoulet C, Desoize B. The authors respectfully acknowledge the funding from Collaborative Health Research Project (#315694-DAN) for financing this research Additionally, the authors would like to thank Anthony Wren, Qiang Li, Shawn McFadden, and Glenn Facey for assisting with aspects of data collection In conclusion, structural analyses on the synthesized glasses show that the addition of Ga leads to the depolymerization of the glass network and increases the fraction of the non-bridging oxygens. 11B MAS NMR analyses showed the addition of Ga reduces the BO 4/BO 3 ratio which indicates an increase in the non-bridging oxygens in the glasses with higher Ga content (Figure 1), and the 31P MAS NMR analyses revealed the presence of orthophosphate units with one and two bridging oxygens and that the introduction of Ga lowers the fraction of units with two bridging oxygens.įigure 1: The 11B NMR spectra for the synthesized glasses Since loose BO 3 units are connected to various branches and cannot be considered a part of any borate superstructural units, their increase can be interpreted as sign of further disruption in the glass network. Raman spectroscopy data showed the incremental addition of Ga results in rise in the fraction of the pentaborate and loose BO 3 units. FTIR results detected small shifts in the position of borate triangles’ peaks in glasses with higher Ga content that indicates short-range order rearrangements. DSC analyses showed a steady decline in glass transition and crystallization temperatures of the glasses with the addition of Ga. XRD results verified the amorphous state of the synthesized glasses. Bruker AVANCE III 200 MHz NMR and Bruker AVANCE 500 MHz NMR were used to produce the 31P and 11B MAS NMR spectra for the samples, respectively. The Raman spectra of the glass powders were studied using a Snowy Range Instruments spectroscopic reader with the laser wavelength of 785 nm. The FTIR spectra of the samples were obtained by Attenuated Total Reflectance (ATR) technique with a ZnSe crystal. A combined differential thermal analyser-thermal gravimetric analyser was used to measure the glass transition and crystallization temperatures. Diffraction patterns were collected using a PAN analytical X-ray diffractometer with a Cu source. Glasses with formulations shown in Table 1 were synthesized using melt-quenching technique.
%) on the structure of zinc borate glass has been investigated using a suite of characterization techniques.
In this study, the impact of increasing concentration of Ga (0-15 wt. Therefore, understanding how the glass structure is affected by the addition of Ga is of great importance in predicting and designing glass formulations that target specific ion release dosages for Ga. However, due to the limits imposed by their toxicity and minimum concentrations needed for their functionality, their effectiveness is dependent on their concentration, which is greatly influenced by the glass structure.
Ga 3+ is also used for the treatment of osteoporosis and cancer-related hypercalcemia. Gallium ions (Ga 3+) released from bioactive glasses can perform multiple therapeutic functions they are known for their antineoplastic, anti-inflammatory, and oligodynamic properties. University of Malaya, Department of Biomedical Engineering, Malaysia Michael’s Hospital, Keenan Research Centre for Biomedical Science, Canada Ryerson University, Department of Mechanical & Industrial Engineering, Canada
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